SMPD3 Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization. Belongs to the neutral sphingomyelinase family. Predominantly expressed in brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Lipid Metabolism - sphingolipid; Membrane protein, integral; Phospholipase
Chromosomal Location of mouse Ortholog: 8|8 D3
Cellular Component:  cytoplasm; Golgi apparatus; Golgi cis cisterna; membrane; plasma membrane
Molecular Function:  hydrolase activity; metal ion binding; neutral sphingomyelin phosphodiesterase activity; phospholipase activity; protein binding; sphingomyelin phosphodiesterase activity
Biological Process:  artery smooth muscle contraction; BMP signaling pathway; bone development; bone growth; bone mineralization; cartilage development; cell cycle; cellular response to hydrogen peroxide; cellular response to magnesium ion; cellular response to oxidised low-density lipoprotein particle stimulus; cellular response to peptide; cellular response to reactive oxygen species; cellular response to redox state; cellular response to tumor necrosis factor; ceramide metabolic process; chondrocyte development; chondrocyte development involved in endochondral bone morphogenesis; collagen metabolic process; dentinogenesis; DNA biosynthetic process; dopamine uptake; endochondral ossification; extracellular matrix assembly; G1 to G0 transition; hematopoietic progenitor cell differentiation; lipid metabolic process; lung alveolus development; lung development; mitotic nuclear division; multicellular organism development; multicellular organism growth; negative regulation of cytosolic calcium ion concentration; negative regulation of hyaluronan biosynthetic process; ossification; peptide hormone secretion; platelet-derived growth factor receptor signaling pathway; polysaccharide transport; positive regulation of ceramide biosynthetic process; positive regulation of exosomal secretion; positive regulation of mitotic nuclear division; positive regulation of NIK/NF-kappaB signaling; positive regulation of nitric oxide biosynthetic process; positive regulation of smooth muscle cell proliferation; protein homooligomerization; protein kinase B signaling; regulation of cartilage development; regulation of hyaluronan biosynthetic process; regulation of leukocyte migration; regulation of protein phosphorylation; respiratory system development; signal transduction; skeletal system development; sphingolipid mediated signaling pathway; sphingolipid metabolic process; sphingomyelin catabolic process; sphingomyelin metabolic process
Reference #:  Q9JJY3 (UniProtKB)
Alt. Names/Synonyms: 4631433G07Rik; AI427456; AW537966; fro; Neutral sphingomyelinase 2; Neutral sphingomyelinase II; nSM; NSMA2; nSMase-2; nSMase2; Smpd3; Sphingomyelin phosphodiesterase 3; sphingomyelin phosphodiesterase 3, neutral
Gene Symbols: Smpd3
Molecular weight: 71,197 Da
Basal Isoelectric point: 5.59  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene