SMPD3 Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization. Belongs to the neutral sphingomyelinase family. Predominantly expressed in brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Lipid Metabolism - sphingolipid; Membrane protein, integral; Phospholipase
Chromosomal Location of human Ortholog: 16q22.1
Cellular Component:  Golgi cis cisterna; Golgi membrane; plasma membrane
Molecular Function:  metal ion binding; neutral sphingomyelin phosphodiesterase activity; protein binding
Biological Process:  BMP signaling pathway; bone growth; bone mineralization; cellular response to hydrogen peroxide; cellular response to magnesium ion; cellular response to oxidised low-density lipoprotein particle stimulus; cellular response to peptide; cellular response to redox state; cellular response to tumor necrosis factor; ceramide metabolic process; chondrocyte development involved in endochondral bone morphogenesis; collagen metabolic process; dentinogenesis; DNA biosynthetic process; endochondral ossification; extracellular matrix assembly; G1 to G0 transition; glycosphingolipid metabolic process; hematopoietic progenitor cell differentiation; lung alveolus development; mitotic nuclear division; multicellular organism growth; negative regulation of hyaluronan biosynthetic process; peptide hormone secretion; platelet-derived growth factor receptor signaling pathway; polysaccharide transport; positive regulation of ceramide biosynthetic process; positive regulation of exosomal secretion; positive regulation of mitotic nuclear division; positive regulation of smooth muscle cell proliferation; protein homooligomerization; protein kinase B signaling; regulation of cartilage development; regulation of leukocyte migration; regulation of protein phosphorylation; sphingolipid mediated signaling pathway; sphingomyelin catabolic process
Reference #:  Q9NY59 (UniProtKB)
Alt. Names/Synonyms: FLJ22593; MGC138443; Neutral sphingomyelinase 2; Neutral sphingomyelinase II; NSMA2; nSMase-2; nSMase2; SMPD3; Sphingomyelin phosphodiesterase 3; sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
Gene Symbols: SMPD3
Molecular weight: 71,081 Da
Basal Isoelectric point: 5.52  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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