VARS Belongs to the class-I aminoacyl-tRNA synthetase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Aminoacyl-tRNA synthetase; EC; Ligase; Translation; Translation regulation
Chromosomal Location of human Ortholog: 6p21.33
Cellular Component:  cytosol
Molecular Function:  aminoacyl-tRNA editing activity; ATP binding; protein binding; valine-tRNA ligase activity
Biological Process:  aminoacyl-tRNA metabolism involved in translational fidelity; tRNA aminoacylation for protein translation; valyl-tRNA aminoacylation
Disease: Neurodevelopmental Disorder With Microcephaly, Seizures, And Cortical Atrophy
Reference #:  P26640 (UniProtKB)
Alt. Names/Synonyms: G7A; NDMSCA; Protein G7a; SYVC; valine tRNA ligase 1, cytoplasmic; Valine--tRNA ligase; ValRS; Valyl-tRNA synthetase; valyl-tRNA synthetase 1; valyl-tRNA synthetase 2; VARS; VARS1; VARS2
Gene Symbols: VARS1
Molecular weight: 140,476 Da
Basal Isoelectric point: 7.53  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene