|
VARS
Belongs to the class-I aminoacyl-tRNA synthetase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Aminoacyl-tRNA synthetase; EC 6.1.1.9; Ligase; Translation; Translation regulation |
| Chromosomal Location of human Ortholog: 6p21.33 |
|
Cellular Component:
cytosol
|
|
Molecular Function:
aminoacyl-tRNA editing activity; ATP binding; protein binding; valine-tRNA ligase activity
|
|
Biological Process:
aminoacyl-tRNA metabolism involved in translational fidelity; tRNA aminoacylation for protein translation; valyl-tRNA aminoacylation
|
|
Disease: Neurodevelopmental Disorder With Microcephaly, Seizures, And Cortical Atrophy
|
|
Reference #:
P26640
(UniProtKB)
|
|
Alt. Names/Synonyms: G7A; NDMSCA; Protein G7a; SYVC; valine tRNA ligase 1, cytoplasmic; Valine--tRNA ligase; ValRS; Valyl-tRNA synthetase; valyl-tRNA synthetase 1; valyl-tRNA synthetase 2; VARS; VARS1; VARS2
|
|
Gene Symbols: VARS1
|
|
Molecular weight:
140,476 Da
|
|
Basal Isoelectric point:
7.53
Predict pI for various phosphorylation states
|
