UBE2E2 Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Belongs to the ubiquitin-conjugating enzyme family. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 3p24.3
Cellular Component: 
Molecular Function:  ATP binding; ISG15 transferase activity; protein binding; ubiquitin conjugating enzyme activity; ubiquitin-protein transferase activity
Biological Process:  cellular response to DNA damage stimulus; ISG15-protein conjugation; positive regulation of G1/S transition of mitotic cell cycle; protein K11-linked ubiquitination; protein K48-linked ubiquitination; protein K63-linked ubiquitination
Reference #:  Q96LR5 (UniProtKB)
Alt. Names/Synonyms: FLJ25157; UB2E2; UBCH8; UBE2E2; Ubiquitin carrier protein E2; Ubiquitin-conjugating enzyme E2 E2; ubiquitin-conjugating enzyme E2E 2 (homologous to yeast UBC4/5); ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast); Ubiquitin-protein ligase E2
Gene Symbols: UBE2E2
Molecular weight: 22,255 Da
Basal Isoelectric point: 7.59  Predict pI for various phosphorylation states
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UBE2E2

Protein Structure Not Found.


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