VRK1 Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily. Widely expressed. Highly expressed in fetal liver, testis and thymus. Note: This description may include information from UniProtKB.
Protein type: CK1 group; EC 2.7.11.1; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor); VRK family
Chromosomal Location of human Ortholog: 14q32.2
Cellular Component:  cytoplasm; cytosol; Golgi stack; nucleolus; nucleoplasm; nucleus
Molecular Function:  ATP binding; histone binding; histone H3S10 kinase activity; histone H3T3 kinase activity; protein binding; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity
Biological Process:  cell division; cellular response to DNA damage stimulus; Golgi disassembly; histone modification; mitotic nuclear membrane disassembly; peptidyl-serine phosphorylation; positive regulation of protein localization to chromatin; protein autophosphorylation; protein phosphorylation; signal transduction
Disease: Pontocerebellar Hypoplasia, Type 1a
Reference #:  Q99986 (UniProtKB)
Alt. Names/Synonyms: MGC117401; MGC138280; MGC142070; PCH1; PCH1A; Serine/threonine-protein kinase VRK1; vaccinia related kinase 1; vaccinia virus B1R-related kinase 1; Vaccinia-related kinase 1; VRK serine/threonine kinase 1; VRK1
Gene Symbols: VRK1
Molecular weight: 45,476 Da
Basal Isoelectric point: 9.02  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

VRK1

Protein Structure Not Found.


Substrate Sequence Logo
Open Substrate Page

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB