VRK1 Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily. Widely expressed. Highly expressed in fetal liver, testis and thymus. Note: This description may include information from UniProtKB.

Protein type: CK1 group; EC 2.7.11.1; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor); VRK family

Chromosomal Location of human Ortholog: 14q32.2

Cellular Component: cytoplasm; cytosol; Golgi stack; nucleolus; nucleoplasm; nucleus

Molecular Function: ATP binding; histone binding; histone H3S10 kinase activity; histone H3T3 kinase activity; protein binding; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity

Biological Process: cell division; chromatin remodeling; DNA damage response; Golgi disassembly; mitotic nuclear membrane disassembly; peptidyl-serine phosphorylation; positive regulation of protein localization to chromatin; protein autophosphorylation; protein phosphorylation; signal transduction

Disease: Neuronopathy, Distal Hereditary Motor, Autosomal Recessive 10; Pontocerebellar Hypoplasia, Type 1a

Reference #: Q99986 (UniProtKB)

Alt. Names/Synonyms: MGC117401; MGC138280; MGC142070; PCH1; PCH1A; Serine/threonine-protein kinase VRK1; vaccinia related kinase 1; vaccinia virus B1R-related kinase 1; Vaccinia-related kinase 1; VRK serine/threonine kinase 1; VRK1

Gene Symbols: VRK1

Molecular weight: 45,476 Da

Basal Isoelectric point: 9.02 Predict pI for various phosphorylation states

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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VRK1

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