UBE2E1 Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination. Belongs to the ubiquitin-conjugating enzyme family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of mouse Ortholog: 14|14 A2
Cellular Component:  nucleus; ubiquitin ligase complex
Molecular Function:  ATP binding; ISG15 transferase activity; nucleotide binding; transferase activity; ubiquitin conjugating enzyme activity; ubiquitin-protein transferase activity
Biological Process:  histone H2B ubiquitination; histone monoubiquitination; ISG15-protein conjugation; protein K48-linked ubiquitination; protein polyubiquitination; protein ubiquitination
Reference #:  P52482 (UniProtKB)
Alt. Names/Synonyms: (E3-independent) E2 ubiquitin-conjugating enzyme E1; E2 ubiquitin-conjugating enzyme E1; UB2E1; Ubce5; ubcM2; UbcM3; Ube2e1; Ubiquitin carrier protein E1; ubiquitin-conjugating enzyme 5; Ubiquitin-conjugating enzyme E2 E1; ubiquitin-conjugating enzyme E2E 1; ubiquitin-conjugating enzyme E2E 1, UBC4/5 homolog; ubiquitin-conjugating enzyme E2E 1, UBC4/5 homolog (yeast); Ubiquitin-protein ligase E1
Gene Symbols: Ube2e1
Molecular weight: 21,333 Da
Basal Isoelectric point: 8.77  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene