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UBE2E1
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination. Belongs to the ubiquitin-conjugating enzyme family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase |
| Chromosomal Location of mouse Ortholog: 14|14 A2 |
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Cellular Component:
nucleus; ubiquitin ligase complex
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Molecular Function:
ATP binding; ISG15 transferase activity; nucleotide binding; transferase activity; ubiquitin conjugating enzyme activity; ubiquitin-protein transferase activity
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Biological Process:
ISG15-protein conjugation; positive regulation of transcription by RNA polymerase II; protein K48-linked ubiquitination; protein polyubiquitination; protein ubiquitination
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Reference #:
P52482
(UniProtKB)
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Alt. Names/Synonyms: (E3-independent) E2 ubiquitin-conjugating enzyme E1; E2 ubiquitin-conjugating enzyme E1; UB2E1; Ubce5; ubcM2; UbcM3; Ube2e1; Ubiquitin carrier protein E1; ubiquitin-conjugating enzyme 5; Ubiquitin-conjugating enzyme E2 E1; ubiquitin-conjugating enzyme E2E 1; ubiquitin-conjugating enzyme E2E 1, UBC4/5 homolog; ubiquitin-conjugating enzyme E2E 1, UBC4/5 homolog (yeast); Ubiquitin-protein ligase E1
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Gene Symbols: Ube2e1
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Molecular weight:
21,333 Da
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Basal Isoelectric point:
8.77
Predict pI for various phosphorylation states
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