UBE2E1 Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination. Belongs to the ubiquitin-conjugating enzyme family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of human Ortholog: 3p24.2
Cellular Component:  cytosol; nucleoplasm; nucleus; ubiquitin ligase complex
Molecular Function:  ATP binding; ISG15 transferase activity; protein binding; ubiquitin conjugating enzyme activity; ubiquitin-protein transferase activity
Biological Process:  anaphase-promoting complex-dependent catabolic process; histone H2B ubiquitination; histone monoubiquitination; ISG15-protein conjugation; protein K48-linked ubiquitination; protein polyubiquitination; protein ubiquitination; regulation of mitotic cell cycle phase transition; ubiquitin-dependent protein catabolic process
Reference #:  P51965 (UniProtKB)
Alt. Names/Synonyms: (E3-independent) E2 ubiquitin-conjugating enzyme E1; E2 ubiquitin-conjugating enzyme E1; UB2E1; UBCH6; UBE2E1; Ubiquitin carrier protein E1; ubiquitin conjugating enzyme E2 E1; ubiquitin conjugating enzyme E2E 1; Ubiquitin-conjugating enzyme E2 E1; ubiquitin-conjugating enzyme E2E 1 (homologous to yeast UBC4/5); ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast); Ubiquitin-protein ligase E1
Gene Symbols: UBE2E1
Molecular weight: 21,404 Da
Basal Isoelectric point: 8.77  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein