TSN DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots. Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand. Belongs to the translin family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; EC 3.1.-.-; Nuclear receptor co-regulator
Chromosomal Location of mouse Ortholog: 1|1 E2.3
Cellular Component:  cytoplasm; endoplasmic reticulum; endoribonuclease complex; male germ cell nucleus; nucleoplasm; nucleus
Molecular Function:  DNA binding; endonuclease activity; hydrolase activity; identical protein binding; mRNA binding; nuclease activity; protein binding; protein-containing complex binding; RNA binding; sequence-specific DNA binding; single-stranded DNA binding
Biological Process:  RNA metabolic process; siRNA processing
Reference #:  Q62348 (UniProtKB)
Alt. Names/Synonyms: 2610034C24Rik; AU040286; C3PO; Component 3 of promoter of RISC; TB-R; TB-RBP; Testis/brain RNA-binding protein; testis/brain-RNA-binding protein; Translin; Tsn
Gene Symbols: Tsn
Molecular weight: 26,201 Da
Basal Isoelectric point: 6.01  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA