TBL1XR1 F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation. Belongs to the WD repeat EBI family. Widely expressed including the pituitary, hypothalamus, white and brown adipose tissue, muscle and liver. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 3|3 A3
Cellular Component:  histone deacetylase complex; mitotic spindle; nucleus; transcriptional repressor complex
Molecular Function:  beta-catenin binding; DNA binding; histone binding; protein binding; protein N-terminus binding; transcription corepressor activity; transcription regulatory region DNA binding
Biological Process:  adipose tissue development; blastocyst hatching; chromatin organization; fat pad development; histone deacetylation; lipid catabolic process; multicellular organism growth; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; positive regulation of canonical Wnt signaling pathway; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of gene expression; regulation of transcription by RNA polymerase II; regulation of triglyceride metabolic process; response to dietary excess; white fat cell differentiation
Reference #:  Q8BHJ5 (UniProtKB)
Alt. Names/Synonyms: 8030499H02Rik; A630076E03Rik; AW539987; C21; C230089I12Rik; DC42; F-box-like/WD repeat protein TBL1XR1; F-box-like/WD repeat-containing protein TBL1XR1; Ira1; Nuclear receptor corepressor/HDAC3 complex subunit TBLR1; TBL1-related protein 1; TBL1R; Tbl1xr1; Tblr1; transducin (beta)-like 1X-linked receptor 1; Transducin beta-like 1X-related protein 1
Gene Symbols: Tbl1xr1
Molecular weight: 55,661 Da
Basal Isoelectric point: 5.33  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA