TBL1XR1 F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation. Belongs to the WD repeat EBI family. Widely expressed including the pituitary, hypothalamus, white and brown adipose tissue, muscle and liver. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of human Ortholog: 3q26.32
Cellular Component:  histone deacetylase complex; mitotic spindle; nucleoplasm; nucleus; transcription repressor complex
Molecular Function:  beta-catenin binding; histone binding; protein binding; transcription cis-regulatory region binding; transcription corepressor activity
Biological Process:  blastocyst hatching; chromatin organization; fat pad development; lipid catabolic process; multicellular organism growth; negative regulation of transcription by RNA polymerase II; positive regulation of canonical Wnt signaling pathway; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of transcription by RNA polymerase II; regulation of triglyceride metabolic process; response to dietary excess; white fat cell differentiation
Disease: Mental Retardation, Autosomal Dominant 41; Pierpont Syndrome
Reference #:  Q9BZK7 (UniProtKB)
Alt. Names/Synonyms: C21; DC42; F-box-like/WD repeat-containing protein TBL1XR1; FLJ12894; IRA1; MRD41; nuclear receptor co-repressor/HDAC3 complex subunit; Nuclear receptor corepressor/HDAC3 complex subunit TBLR1; TBL1-related protein 1; TBL1R; TBL1X receptor 1; TBL1XR1; TBLR1; transducin (beta)-like 1 X-linked receptor 1; transducin beta like 1 X-linked receptor 1; Transducin beta-like 1X-related protein 1
Gene Symbols: TBL1XR1
Molecular weight: 55,595 Da
Basal Isoelectric point: 5.28  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein