MAK Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors. Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Expressed in prostate cancer cell lines at generally higher levels than in normal prostate epithelial cell lines. Isoform 1 is expressed in kidney, testis, lung, trachea, and retina. Isoform 2 is retina-specific where it is expressed in rod and cone photoreceptors. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CMGC group; EC; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); RCK family
Chromosomal Location of Human Ortholog: 6p24.2
Cellular Component:  axoneme; centrosome; midbody; mitotic spindle; motile cilium; nucleus; photoreceptor connecting cilium; photoreceptor inner segment; photoreceptor outer segment
Molecular Function:  ATP binding; metal ion binding; protein binding; protein kinase activity; transcription coactivator activity
Biological Process:  cell differentiation; multicellular organism development; negative regulation of non-motile cilium assembly; photoreceptor cell maintenance; positive regulation of nucleic acid-templated transcription; protein autophosphorylation; protein phosphorylation; spermatogenesis
Disease: Retinitis Pigmentosa 62
Reference #:  P20794 (UniProtKB)
Alt. Names/Synonyms: dJ417M14.2; MAK; Male germ cell-associated kinase; serine/threonine protein kinase MAK; Serine/threonine-protein kinase MAK
Gene Symbols: MAK
Molecular weight: 70,581 Da
Basal Isoelectric point: 9.67  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA