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TBL1X
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange. Belongs to the WD repeat EBI family. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor |
| Chromosomal Location of Human Ortholog: X B|X 38.31 cM |
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Cellular Component:
histone deacetylase complex; mitotic spindle; nucleus; transcription factor complex; transcriptional repressor complex
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Molecular Function:
beta-catenin binding; chromatin binding; DNA binding; histone binding; identical protein binding; protein binding; protein C-terminus binding; protein domain specific binding; transcription corepressor activity; transcription factor binding; transcription regulatory region DNA binding
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Biological Process:
fat cell differentiation; histone deacetylation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; positive regulation of canonical Wnt signaling pathway; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; proteasome-mediated ubiquitin-dependent protein catabolic process; protein stabilization; proteolysis; regulation of transcription by RNA polymerase II; response to estrogen; response to steroid hormone; sensory perception of sound
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Reference #:
Q9QXE7
(UniProtKB)
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Alt. Names/Synonyms: 5330429M20; F-box-like/WD repeat-containing protein TBL1X; OTTMUSP00000019452; Tbl1; Tbl1x; transducin (beta)-like 1 X-linked; Transducin beta-like protein 1X
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Gene Symbols: Tbl1x
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Molecular weight:
56,802 Da
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Basal Isoelectric point:
5.4
Predict pI for various phosphorylation states
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CST Pathways:
Protein Acetylation
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