|
TBL1X
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange. Belongs to the WD repeat EBI family. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor |
| Chromosomal Location of mouse Ortholog: X B|X 38.31 cM |
|
Cellular Component:
histone deacetylase complex; mitotic spindle; nucleoplasm; nucleus; transcription regulator complex; transcription repressor complex
|
|
Molecular Function:
chromatin binding; DNA binding; histone binding; identical protein binding; protein binding; transcription cis-regulatory region binding; transcription corepressor activity
|
|
Biological Process:
fat cell differentiation; negative regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; protein stabilization; regulation of transcription by RNA polymerase II; response to estrogen; response to steroid hormone
|
|
Reference #:
Q9QXE7
(UniProtKB)
|
|
Alt. Names/Synonyms: 5330429M20; F-box-like/WD repeat-containing protein TBL1X; OTTMUSP00000019452; Tbl; Tbl1; Tbl1x; transducin (beta)-like 1 X-linked; Transducin beta-like protein 1X
|
|
Gene Symbols: Tbl1x
|
|
Molecular weight:
56,802 Da
|
|
Basal Isoelectric point:
5.4
Predict pI for various phosphorylation states
|
|
CST Pathways:
Protein Acetylation
|
