TBL1X F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange. Belongs to the WD repeat EBI family. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of human Ortholog: Xp22.31-p22.2
Cellular Component:  histone deacetylase complex; mitotic spindle; nucleoplasm; nucleus; transcriptional repressor complex
Molecular Function:  beta-catenin binding; histone binding; protein binding; protein C-terminus binding; protein domain specific binding; transcription corepressor activity; transcription factor binding; transcription regulatory region DNA binding
Biological Process:  negative regulation of transcription by RNA polymerase II; positive regulation of canonical Wnt signaling pathway; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; proteasome-mediated ubiquitin-dependent protein catabolic process; protein stabilization; proteolysis; regulation of lipid metabolic process; sensory perception of sound
Disease: Hypothyroidism, Congenital, Nongoitrous, 8
Reference #:  O60907 (UniProtKB)
Alt. Names/Synonyms: CHNG8; EBI; F-box-like/WD repeat-containing protein TBL1X; SMAP55; TBL1; TBL1X; transducin (beta)-like 1X-linked; transducin beta like 1 X-linked; transducin beta like 1X-linked; transducin beta-like 1X; Transducin beta-like protein 1X; Transducin-beta-like protein 1, X-linked
Gene Symbols: TBL1X
Molecular weight: 62,496 Da
Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein