STAU Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site. (Microbial infection) Plays a role in virus particles production of many viruses including of HIV-1, HERV-K, ebola virus and influenza virus. Acts by interacting with various viral proteins involved in particle budding process. Widely expressed. Expressed in brain, pancreas, heart, skeletal muscles, liver, lung, kidney and placenta. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding
Chromosomal Location of mouse Ortholog: 2|2 H3
Cellular Component:  cell body; cytoplasm; cytoplasmic ribonucleoprotein granule; cytoplasmic stress granule; cytosol; dendrite; endoplasmic reticulum; glutamatergic synapse; neuron projection; neuronal cell body; plasma membrane; ribonucleoprotein complex
Molecular Function:  double-stranded RNA binding; protein binding; protein phosphatase 1 binding; RNA binding
Biological Process:  dendritic transport of messenger ribonucleoprotein complex; intracellular mRNA localization; modification of postsynaptic structure; modulation of chemical synaptic transmission; positive regulation by virus of viral protein levels in host cell; positive regulation of long-term synaptic potentiation; positive regulation of viral genome replication
Reference #:  Q9Z108 (UniProtKB)
Alt. Names/Synonyms: 5830401L18Rik; AW549911; C85792; Double-stranded RNA-binding protein Staufen homolog 1; OTTMUSP00000001080; Stau; Stau1; staufen (RNA binding protein) homolog 1; staufen (RNA binding protein) homolog 1 (Drosophila); staufen double-stranded RNA binding protein 1
Gene Symbols: Stau1
Molecular weight: 53,925 Da
Basal Isoelectric point: 9.55  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene