STAU Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site. (Microbial infection) Plays a role in virus particles production of many viruses including of HIV-1, HERV-K, ebola virus and influenza virus. Acts by interacting with various viral proteins involved in particle budding process. Widely expressed. Expressed in brain, pancreas, heart, skeletal muscles, liver, lung, kidney and placenta. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding
Chromosomal Location of Human Ortholog: 20q13.13
Cellular Component:  cell body; cytoplasm; cytoplasmic ribonucleoprotein granule; cytoplasmic stress granule; cytosol; dendrite; endoplasmic reticulum; glutamatergic synapse; microtubule associated complex; neuronal cell body; plasma membrane; rough endoplasmic reticulum
Molecular Function:  double-stranded RNA binding; protein binding; protein phosphatase 1 binding
Biological Process:  cellular response to oxidative stress; modification of postsynaptic structure; positive regulation by virus of viral protein levels in host cell; positive regulation of long-term synaptic potentiation; positive regulation of viral genome replication; viral process
Reference #:  O95793 (UniProtKB)
Alt. Names/Synonyms: Double-stranded RNA-binding protein Staufen homolog 1; FLJ25010; PPP1R150; protein phosphatase 1, regulatory subunit 150; STAU; STAU1; staufen double-stranded RNA binding protein 1; staufen, RNA binding protein, homolog 1; staufen, RNA binding protein, homolog 1 (Drosophila)
Gene Symbols: STAU1
Molecular weight: 63,182 Da
Basal Isoelectric point: 9.46  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein