DCAMKL1 Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. In fetal tissues, highly expressed in brain, detectable in lung and liver, but not in kidney. In adult tissues, expressed ubiquitously in the brain, detectable in the heart, liver, spleen, thymus, prostate, testis, ovary, small intestine and colon. The type A isoforms seem to be expressed predominantly in fetal brain whereas type B isoforms are expressed abundantly in both fetal and adult brain. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CAMK group; DCAMKL family; EC 2.7.11.1; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 13q13.3
Cellular Component:  integral component of plasma membrane; postsynaptic density
Molecular Function:  ATP binding; protein kinase activity; protein serine/threonine kinase activity
Biological Process:  axon extension; central nervous system development; central nervous system projection neuron axonogenesis; dendrite morphogenesis; endosomal transport; forebrain development; intracellular signal transduction; negative regulation of protein localization to nucleus; nervous system development; neuron migration; peptidyl-serine phosphorylation; protein phosphorylation; response to virus
Reference #:  O15075 (UniProtKB)
Alt. Names/Synonyms: CL1; CLICK1; DCAMKL1; DCDC3A; DCLK; DCLK1; doublecortin and CaM kinase-like 1; Doublecortin domain-containing protein 3A; Doublecortin-like and CAM kinase-like 1; Doublecortin-like kinase 1; KIAA0369; Serine/threonine-protein kinase DCLK1
Gene Symbols: DCLK1
Molecular weight: 82,224 Da
Basal Isoelectric point: 8.84  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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DCAMKL1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein