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DCAMKL1
Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. In fetal tissues, highly expressed in brain, detectable in lung and liver, but not in kidney. In adult tissues, expressed ubiquitously in the brain, detectable in the heart, liver, spleen, thymus, prostate, testis, ovary, small intestine and colon. The type A isoforms seem to be expressed predominantly in fetal brain whereas type B isoforms are expressed abundantly in both fetal and adult brain. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: CAMK group; DCAMKL family; EC 2.7.11.1; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of human Ortholog: 13q13.3 |
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Cellular Component:
plasma membrane; postsynaptic density
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Molecular Function:
ATP binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity
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Biological Process:
axon extension; central nervous system development; central nervous system projection neuron axonogenesis; dendrite morphogenesis; endosomal transport; forebrain development; intracellular signal transduction; negative regulation of protein localization to nucleus; nervous system development; neuron migration; neuron projection morphogenesis; peptidyl-serine phosphorylation; protein localization to nucleus; protein phosphorylation; response to virus
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Reference #:
O15075
(UniProtKB)
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Alt. Names/Synonyms: CL1; CLICK1; DCAMKL1; DCDC3A; DCLK; DCLK1; doublecortin and CaM kinase-like 1; Doublecortin domain-containing protein 3A; doublecortin like kinase 1; Doublecortin-like and CAM kinase-like 1; Doublecortin-like kinase 1; KIAA0369; Serine/threonine-protein kinase DCLK1
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Gene Symbols: DCLK1
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Molecular weight:
82,224 Da
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Basal Isoelectric point:
8.84
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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