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SORBS1
Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions. Detected in skeletal muscle (at protein level). Widely expressed with highest levels in heart and skeletal muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 19 C3|19 34.25 cM |
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Cellular Component:
adherens junction; anchoring junction; cell-substrate junction; centrosome; cytoplasm; cytoskeleton; cytosol; flotillin complex; focal adhesion; membrane; membrane raft; nuclear matrix; nucleus; plasma membrane; stress fiber; synapse
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Molecular Function:
insulin receptor binding; protein binding; protein kinase binding; signaling receptor complex adaptor activity; ubiquitin protein ligase binding
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Biological Process:
acetylcholine receptor signaling pathway; cell-substrate adhesion; cellular response to insulin stimulus; focal adhesion assembly; insulin receptor signaling pathway; positive regulation of glucose import; positive regulation of glycogen biosynthetic process; positive regulation of insulin receptor signaling pathway; positive regulation of lipid biosynthetic process; positive regulation of protein localization to plasma membrane; regulation of skeletal muscle acetylcholine-gated channel clustering; stress fiber assembly
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Reference #:
Q62417
(UniProtKB)
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Alt. Names/Synonyms: 2310065E01Rik; 9530001P15Rik; c-Cbl-associated protein; CAP; Kiaa1296; mKIAA1296; Ponsin; SH3 domain protein 5; Sh3d; Sh3d5; SH3P12; sorbin and SH3 domain containing 1; Sorbin and SH3 domain-containing protein 1; Sorbs1; SRBS1
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Gene Symbols: Sorbs1
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Molecular weight:
143,070 Da
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Basal Isoelectric point:
8.48
Predict pI for various phosphorylation states
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CST Pathways:
Insulin Receptor Signaling
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