SHMT1 Interconversion of serine and glycine. Belongs to the SHMT family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - glycine, serine and threonine; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC; Energy Metabolism - methane; Lyase; Methyltransferase; Mitochondrial; Other Amino Acids Metabolism - cyanoamino acid
Chromosomal Location of human Ortholog: 17p11.2
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function:  glycine hydroxymethyltransferase activity; identical protein binding; mRNA 5'-UTR binding; mRNA regulatory element binding translation repressor activity; protein binding; protein homodimerization activity; pyridoxal phosphate binding; serine binding; small molecule binding; zinc ion binding
Biological Process:  cellular response to leukemia inhibitory factor; cellular response to tetrahydrofolate; dTMP biosynthetic process; folic acid metabolic process; glycine biosynthetic process from serine; glycine metabolic process; L-serine catabolic process; L-serine metabolic process; negative regulation of translation; protein homotetramerization; purine nucleobase biosynthetic process; tetrahydrofolate interconversion; tetrahydrofolate metabolic process
Reference #:  P34896 (UniProtKB)
Alt. Names/Synonyms: 14 kDa protein; CSHMT; cytoplasmic serine hydroxymethyltransferase; GLYC; Glycine hydroxymethyltransferase; MGC15229; MGC24556; serine hydroxymethyltransferase 1; serine hydroxymethyltransferase 1 (soluble); Serine hydroxymethyltransferase, cytosolic; Serine methylase; SHMT; SHMT1
Gene Symbols: SHMT1
Molecular weight: 53,083 Da
Basal Isoelectric point: 7.61  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein