SEPT9 Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. Widely expressed. Isoforms are differentially expressed in testes, kidney, liver heart, spleen, brain, peripheral blood leukocytes, skeletal muscle and kidney. Specific isoforms appear to demonstrate tissue specificity. Isoform 5 is the most highly expressed in fetal tissue. Isoform 1 is detected in all tissues except the brain and thymus, while isoform 2, isoform 3, and isoform 4 are detected at low levels in approximately half of the fetal tissues. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Cytoskeletal; Hydrolase
Chromosomal Location of mouse Ortholog: 11 E2|11 82.61 cM
Cellular Component:  actin cytoskeleton; axoneme; cytoplasm; cytoskeleton; microtubule; microtubule cytoskeleton; non-motile cilium; perinuclear region of cytoplasm; septin complex; septin ring; stress fiber
Molecular Function:  GTP binding; GTPase activity; nucleotide binding; protein binding
Biological Process:  cell cycle; cell division; cytoskeleton-dependent cytokinesis; positive regulation of non-motile cilium assembly; protein heterooligomerization
Reference #:  Q80UG5 (UniProtKB)
Alt. Names/Synonyms: Kiaa0991; MLL septin-like fusion; MLL septin-like fusion partner; Msf; MSF1; OTTMUSP00000004045; OTTMUSP00000004046; PNU; PNUTL4; Sep; Sept9; septin 9; Septin-9; Septin9; Sint1; SL3-3 integration site 1 protein
Gene Symbols: Septin9
Molecular weight: 65,575 Da
Basal Isoelectric point: 9.01  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene