CLK2
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. Endothelial cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
Protein type: CLK family; CMGC group; EC 2.7.12.1; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) |
Chromosomal Location of human Ortholog: 1q22 |
Cellular Component:
nuclear body; nuclear speck; nucleoplasm; nucleus
|
Molecular Function:
ATP binding; identical protein binding; protein binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity
|
Biological Process:
negative regulation of gluconeogenesis; peptidyl-tyrosine phosphorylation; protein autophosphorylation; protein phosphorylation; regulation of RNA splicing; response to ionizing radiation
|
Reference #:
P49760
(UniProtKB)
|
Alt. Names/Synonyms: CDC like kinase 2; CDC-like kinase 2; CLK kinase; CLK2; Dual specificity protein kinase CLK2; hCLK2; MGC61500
|
Gene Symbols: CLK2
|
Molecular weight:
60,090 Da
|
Basal Isoelectric point:
9.69
Predict pI for various phosphorylation states
|