RPL5 Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Belongs to the universal ribosomal protein uL18 family. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; Ribosomal; Translation
Cellular Component:  aminoacyl-tRNA synthetase multienzyme complex; cytoplasm; cytosol; cytosolic large ribosomal subunit; cytosolic ribosome; endoplasmic reticulum; nucleolus; nucleoplasm; nucleus; postsynaptic density; protein-containing complex; ribonucleoprotein complex; ribosome; synapse
Molecular Function:  5S rRNA binding; mRNA 3'-UTR binding; mRNA 5'-UTR binding; mRNA binding; protein binding; RNA binding; rRNA binding; structural constituent of ribosome; ubiquitin ligase inhibitor activity; ubiquitin protein ligase binding
Biological Process:  negative regulation of protein neddylation; negative regulation of ubiquitin protein ligase activity; negative regulation of ubiquitin-dependent protein catabolic process; positive regulation of gene expression; positive regulation of isoleucine-tRNA ligase activity; positive regulation of methionine-tRNA ligase activity; positive regulation of phosphatase activity; positive regulation of threonine-tRNA ligase activity; positive regulation of translation; protein stabilization; regulation of signal transduction by p53 class mediator; ribosomal large subunit assembly; ribosomal large subunit biogenesis; rRNA processing; translation
Reference #:  P47962 (UniProtKB)
Alt. Names/Synonyms: 60S ribosomal protein L5; MGC101934; MGC117998; ribosomal protein L5; RL5; Rpl5; U21; U21RNA
Gene Symbols: Rpl5
Molecular weight: 34,401 Da
Basal Isoelectric point: 9.78  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein