RPL5 Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Belongs to the universal ribosomal protein uL18 family. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; Ribosomal; Translation
Chromosomal Location of human Ortholog: 1p22.1
Cellular Component:  cytoplasm; cytosol; cytosolic large ribosomal subunit; cytosolic ribosome; endoplasmic reticulum; nucleolus; nucleoplasm; nucleus; protein-containing complex; ribonucleoprotein complex
Molecular Function:  5S rRNA binding; mRNA 3'-UTR binding; mRNA 5'-UTR binding; protein binding; structural constituent of ribosome; ubiquitin ligase inhibitor activity; ubiquitin protein ligase binding
Biological Process:  cytoplasmic translation; negative regulation of protein neddylation; negative regulation of ubiquitin protein ligase activity; negative regulation of ubiquitin-dependent protein catabolic process; positive regulation of gene expression; positive regulation of translation; protein stabilization; regulation of signal transduction by p53 class mediator; ribosomal large subunit assembly; ribosomal large subunit biogenesis; rRNA processing; translation
Disease: Diamond-blackfan Anemia 6
Reference #:  P46777 (UniProtKB)
Alt. Names/Synonyms: 60S ribosomal protein L5; DBA6; L5; Large ribosomal subunit protein uL18; MGC117339; MSTP030; PPP1R135; protein phosphatase 1, regulatory subunit 135; ribosomal protein L5; RL5; RPL5; uL18
Gene Symbols: RPL5
Molecular weight: 34,363 Da
Basal Isoelectric point: 9.73  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein