ROD1 RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U). Expressed in several hematopoietic cell lines examined. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding
Chromosomal Location of human Ortholog: 9q32
Cellular Component:  nucleus
Biological Process:  anatomical structure morphogenesis; erythrocyte maturation; mRNA processing; negative regulation of RNA splicing; regulation of cell differentiation; RNA splicing
Reference #:  O95758 (UniProtKB)
Alt. Names/Synonyms: DKFZp781I1117; fission yeast differentiation regulator; polypyrimidine tract binding protein 3; Polypyrimidine tract-binding protein 3; PTBP3; Regulator of differentiation 1; ROD1; ROD1 regulator of differentiation 1; ROD1 regulator of differentiation 1 (S. pombe)
Gene Symbols: PTBP3
Molecular weight: 59,690 Da
Basal Isoelectric point: 9.13  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein