RARS Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1. Belongs to the class-I aminoacyl-tRNA synthetase family. 2 alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Aminoacyl-tRNA synthetase; EC 6.1.1.19; Ligase; Mitochondrial; RNA-binding; Translation; Translation regulation
Chromosomal Location of Human Ortholog: 11|11 A4
Cellular Component:  aminoacyl-tRNA synthetase multienzyme complex; cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function:  aminoacyl-tRNA ligase activity; arginine binding; arginine-tRNA ligase activity; ATP binding; ligase activity; nucleotide binding; tRNA binding
Biological Process:  arginyl-tRNA aminoacylation; translation; tRNA aminoacylation for protein translation
Reference #:  Q9D0I9 (UniProtKB)
Alt. Names/Synonyms: 2610011N19Rik; 2610037E21Rik; AL033339; Arginine--tRNA ligase; Arginine--tRNA ligase, cytoplasmic; arginyl-tRNA synthetase; Arginyl-tRNA synthetase, cytoplasmic; ArgRS; AW985894; OTTMUSP00000005592; Rars; SYRC
Gene Symbols: Rars
Molecular weight: 75,674 Da
Basal Isoelectric point: 7.48  Predict pI for various phosphorylation states
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RARS

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene