PSMD11 Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity. Belongs to the proteasome subunit S9 family. Highly expressed in embryonic stem cells (ESCs). Expression decreases as ESCs differentiate. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Protease; Proteasome complex
Chromosomal Location of Human Ortholog: 11|11 B5
Cellular Component:  proteasome accessory complex; proteasome complex; proteasome regulatory particle; proteasome regulatory particle, lid subcomplex
Molecular Function:  protein binding; structural molecule activity
Biological Process:  proteasome assembly; stem cell differentiation; ubiquitin-dependent protein catabolic process
Reference #:  Q8BG32 (UniProtKB)
Alt. Names/Synonyms: 1700089D09Rik; 1810019E17Rik; 2610024G20Rik; 26S proteasome non-ATPase regulatory subunit 11; 26S proteasome regulatory subunit p44.5; 26S proteasome regulatory subunit S9; 2810055C24Rik; C78232; OTTMUSP00000000274; P44.5; proteasome (prosome, macropain) 26S subunit, non-ATPase, 11; PSD11; Psmd11; S9
Gene Symbols: Psmd11
Molecular weight: 47,437 Da
Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PSMD11

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene