PSMD11 Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity. Belongs to the proteasome subunit S9 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protease; Proteasome complex
Chromosomal Location of Human Ortholog: 11|11 B5
Cellular Component:  proteasome accessory complex; proteasome complex; proteasome regulatory particle; proteasome regulatory particle, lid subcomplex
Molecular Function:  protein binding; structural molecule activity
Biological Process:  proteasome assembly; stem cell differentiation; ubiquitin-dependent protein catabolic process
Reference #:  Q8BG32 (UniProtKB)
Alt. Names/Synonyms: 1700089D09Rik; 1810019E17Rik; 2610024G20Rik; 26S proteasome non-ATPase regulatory subunit 11; 26S proteasome regulatory subunit p44.5; 26S proteasome regulatory subunit S9; 2810055C24Rik; C78232; OTTMUSP00000000274; P44.5; proteasome (prosome, macropain) 26S subunit, non-ATPase, 11; PSD11; Psmd11; S9
Gene Symbols: Psmd11
Molecular weight: 47,437 Da
Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PSMD11

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene