PSMD10 Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protease; Proteasome complex
Chromosomal Location of Human Ortholog: X|X F1
Cellular Component:  cytoplasm; cytosol; intermediate filament cytoskeleton; nucleus; proteasome complex; proteasome regulatory particle, base subcomplex
Molecular Function:  protein binding; transcription factor binding
Biological Process:  apoptosis; cytoplasmic sequestering of NF-kappaB; negative regulation of apoptosis; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of MAPKKK cascade; negative regulation of NF-kappaB transcription factor activity; negative regulation of release of cytochrome c from mitochondria; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell growth; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein ubiquitination; proteasome regulatory particle assembly
Reference #:  Q9Z2X2 (UniProtKB)
Alt. Names/Synonyms: 26S proteasome non-ATPase regulatory subunit 10; 26S proteasome regulatory subunit p28; AW554874; Gankyrin; OTTMUSP00000020445; proteasome (prosome, macropain) 26S subunit, non-ATPase, 10; proteasome subunit p28; proteosome (prosome, macropain) 26S subunit, non-ATPase, 10; proteosome subunit p28; PSD10; Psmd10
Gene Symbols: Psmd10
Molecular weight: 25,084 Da
Basal Isoelectric point: 5.68  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PSMD10

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene