PSMD10 Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis. Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export. Tends to be up-regulated in cancer cells with RAS mutations, including lung cancers and adenocarconimas (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Protease; Proteasome complex
Chromosomal Location of human Ortholog: Xq22.3
Cellular Component:  cytoplasm; cytoskeleton; cytosol; intermediate filament cytoskeleton; neuron projection; nucleoplasm; nucleus; plasma membrane; proteasome complex
Molecular Function:  cytoskeletal protein binding; protein binding; protein-macromolecule adaptor activity; RNA polymerase II-specific DNA-binding transcription factor binding; transcription factor binding; transmembrane transporter binding
Biological Process:  apoptotic process; cytoplasmic sequestering of NF-kappaB; negative regulation of apoptotic process; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of MAPK cascade; negative regulation of NF-kappaB transcription factor activity; negative regulation of release of cytochrome c from mitochondria; negative regulation of transcription by RNA polymerase II; positive regulation of cell growth; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein ubiquitination; proteasome regulatory particle assembly; protein localization to plasma membrane; regulation of transcription by RNA polymerase II
Reference #:  O75832 (UniProtKB)
Alt. Names/Synonyms: 26S proteasome non-ATPase regulatory subunit 10; 26S proteasome regulatory subunit p28; ankyrin repeat protein; dJ889N15.2; Gankyrin; hepatocellular carcinoma-associated protein p28-II; p28; p28(GANK); proteasome (prosome, macropain) 26S subunit, non-ATPase, 10; proteasome 26S non-ATPase subunit 10; proteasome 26S subunit, non-ATPase 10; PSD10; PSMD10
Gene Symbols: PSMD10
Molecular weight: 24,428 Da
Basal Isoelectric point: 5.71  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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