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PSMD10
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Protease; Proteasome complex |
| Chromosomal Location of Human Ortholog: Xq22.3 |
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Cellular Component:
cytoplasm; cytosol; intermediate filament cytoskeleton; nucleoplasm; nucleus; proteasome complex
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Molecular Function:
protein binding; transcription factor binding
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Biological Process:
anaphase-promoting complex-dependent catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; apoptotic process; cytoplasmic sequestering of NF-kappaB; Fc-epsilon receptor signaling pathway; interleukin-1-mediated signaling pathway; MAPK cascade; negative regulation of apoptotic process; negative regulation of canonical Wnt signaling pathway; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of G2/M transition of mitotic cell cycle; negative regulation of MAPK cascade; negative regulation of NF-kappaB transcription factor activity; negative regulation of release of cytochrome c from mitochondria; negative regulation of transcription by RNA polymerase II; NIK/NF-kappaB signaling; positive regulation of canonical Wnt signaling pathway; positive regulation of cell growth; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein ubiquitination; post-translational protein modification; proteasome regulatory particle assembly; proteasome-mediated ubiquitin-dependent protein catabolic process; protein deubiquitination; protein polyubiquitination; regulation of cellular amino acid metabolic process; regulation of hematopoietic stem cell differentiation; regulation of mitotic cell cycle phase transition; regulation of mRNA stability; regulation of transcription from RNA polymerase II promoter in response to hypoxia; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; transmembrane transport; tumor necrosis factor-mediated signaling pathway; Wnt signaling pathway, planar cell polarity pathway
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Reference #:
O75832
(UniProtKB)
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Alt. Names/Synonyms: 26S proteasome non-ATPase regulatory subunit 10; 26S proteasome regulatory subunit p28; ankyrin repeat protein; dJ889N15.2; Gankyrin; hepatocellular carcinoma-associated protein p28-II; p28; proteasome (prosome, macropain) 26S subunit, non-ATPase, 10; proteasome 26S non-ATPase subunit 10; PSD10; PSMD10
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Gene Symbols: PSMD10
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Molecular weight:
24,428 Da
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Basal Isoelectric point:
5.71
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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