RPT4 Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. Belongs to the AAA ATPase family. Note: This description may include information from UniProtKB.

Protein type: Protease; Proteasome complex

Chromosomal Location of human Ortholog: 14q22.1

Cellular Component: cytosol; cytosolic proteasome complex; inclusion body; nucleoplasm; nucleus; proteasome accessory complex; proteasome complex; proteasome regulatory particle, base subcomplex

Molecular Function: ATP binding; ATP hydrolysis activity; identical protein binding; proteasome-activating activity; protein binding; protein-macromolecule adaptor activity

Biological Process: positive regulation of inclusion body assembly; positive regulation of proteasomal protein catabolic process; positive regulation of RNA polymerase II transcription preinitiation complex assembly; proteasome-mediated ubiquitin-dependent protein catabolic process; ubiquitin-dependent ERAD pathway

Reference #: P62333 (UniProtKB)

Alt. Names/Synonyms: 26S protease regulatory subunit S10B; 26S proteasome AAA-ATPase subunit RPT4; 26S proteasome regulatory subunit 10B; CADP44; conserved ATPase domain protein 44; MGC12520; p42; P44; proteasome (prosome, macropain) 26S subunit, ATPase, 6; Proteasome 26S subunit ATPase 6; proteasome 26S subunit, ATPase 6; Proteasome subunit p42; PRS10; PSMC6; RPT4; SUG2

Gene Symbols: PSMC6

Molecular weight: 44,173 Da

Basal Isoelectric point: 7.09 Predict pI for various phosphorylation states

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RPT4

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