RPT6 Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. Belongs to the AAA ATPase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: Nuclear receptor co-regulator; Proteasome complex; Ubiquitin conjugating system

Chromosomal Location of human Ortholog: 17q23.3

Cellular Component: cytoplasm; cytoplasmic vesicle; cytosol; nucleoplasm; nucleus; proteasome accessory complex; proteasome complex; proteasome regulatory particle, base subcomplex

Molecular Function: ATP binding; ATP hydrolysis activity; DNA-binding transcription factor binding; general transcription initiation factor binding; proteasome-activating activity; protein binding; thyrotropin-releasing hormone receptor binding; transcription factor binding

Biological Process: negative regulation of DNA-templated transcription; negative regulation of programmed cell death; positive regulation of DNA-templated transcription; positive regulation of proteasomal protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of transcription by RNA polymerase II

Reference #: P62195 (UniProtKB)

Alt. Names/Synonyms: 26S protease regulatory subunit 8; 26S proteasome AAA-ATPase subunit RPT6; 26S proteasome regulatory subunit 8; MSUG1 protein; p45; p45/SUG; proteasome (prosome, macropain) 26S subunit, ATPase, 5; proteasome 26S ATPase subunit 5; Proteasome 26S subunit ATPase 5; proteasome 26S subunit, ATPase 5; Proteasome subunit p45; PRS8; PSMC5; RPT6; S8; SUG-1; SUG1; Tat-binding protein homolog 10; TBP10; testicular tissue protein Li 149; Thyroid hormone receptor-interacting protein 1; thyroid receptor interactor 1; TRIP1

Gene Symbols: PSMC5

Molecular weight: 45,626 Da

Basal Isoelectric point: 7.11 Predict pI for various phosphorylation states

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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RPT6

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