RPT5 The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. In case of HIV-1 infection, suppresses Tat-mediated transactivation. Belongs to the AAA ATPase family. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Proteasome complex; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 2 E1|2 50.44 cM
Cellular Component:  cytoplasm; nucleus; P-body; perinuclear region of cytoplasm; proteasome accessory complex; proteasome complex; proteasome regulatory particle, base subcomplex
Molecular Function:  ATP binding; hydrolase activity; identical protein binding; nucleotide binding; proteasome-activating ATPase activity
Biological Process:  blastocyst development; modulation by host of viral transcription; positive regulation of RNA polymerase II transcriptional preinitiation complex assembly; positive regulation of transcription by RNA polymerase II; protein catabolic process
Reference #:  O88685 (UniProtKB)
Alt. Names/Synonyms: 26S protease regulatory subunit 6A; 26S proteasome AAA-ATPase subunit RPT5; 26S proteasome regulatory subunit 6A; OTTMUSP00000015162; proteasome (prosome, macropain) 26S subunit, ATPase 3; Proteasome 26S subunit ATPase 3; PRS6A; Psmc3; RPT5; Tat binding protein 1; Tat-binding protein 1; TBP-1; Tbp1
Gene Symbols: Psmc3
Molecular weight: 49,549 Da
Basal Isoelectric point: 5.09  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA