RPT5 Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. Belongs to the AAA ATPase family. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Proteasome complex; Transcription, coactivator/corepressor
Chromosomal Location of human Ortholog: 11p11.2
Cellular Component:  cytosol; extracellular region; ficolin-1-rich granule lumen; nucleoplasm; nucleus; P-body; proteasome accessory complex; proteasome complex; secretory granule lumen
Molecular Function:  ATP binding; ATPase activity; identical protein binding; proteasome-activating ATPase activity; protein binding
Biological Process:  anaphase-promoting complex-dependent catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; blastocyst development; Fc-epsilon receptor signaling pathway; interleukin-1-mediated signaling pathway; MAPK cascade; modulation by host of viral transcription; negative regulation of canonical Wnt signaling pathway; negative regulation of G2/M transition of mitotic cell cycle; neutrophil degranulation; NIK/NF-kappaB signaling; positive regulation of canonical Wnt signaling pathway; positive regulation of proteasomal protein catabolic process; positive regulation of transcription by RNA polymerase II; post-translational protein modification; proteasome-mediated ubiquitin-dependent protein catabolic process; protein deubiquitination; protein polyubiquitination; regulation of cellular amino acid metabolic process; regulation of hematopoietic stem cell differentiation; regulation of mitotic cell cycle phase transition; regulation of mRNA stability; regulation of transcription from RNA polymerase II promoter in response to hypoxia; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; transmembrane transport; tumor necrosis factor-mediated signaling pathway; viral process; Wnt signaling pathway, planar cell polarity pathway
Disease: Deafness, Cataract, Impaired Intellectual Development, And Polyneuropathy
Reference #:  P17980 (UniProtKB)
Alt. Names/Synonyms: 26S protease regulatory subunit 6A; 26S proteasome AAA-ATPase subunit RPT5; 26S proteasome regulatory subunit 6A; human immunodeficiency virus tat transactivator binding protein-1; MGC8487; proteasome (prosome, macropain) 26S subunit, ATPase, 3; Proteasome 26S subunit ATPase 3; proteasome 26S subunit, ATPase 3; Proteasome subunit P50; PRS6A; PSMC3; RPT5; Tat-binding protein 1; TBP-1; TBP1; testicular secretory protein Li 42
Gene Symbols: PSMC3
Molecular weight: 49,204 Da
Basal Isoelectric point: 5.13  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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RPT5

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA