PSMA6 Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Belongs to the peptidase T1A family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: EC 3.4.25.1; Protease; Proteasome complex

Chromosomal Location of human Ortholog: 14q13.2

Cellular Component: cytoplasm; cytosol; myofibril; nuclear matrix; nucleoplasm; nucleus; P-body; polysome; proteasome complex; proteasome core complex; proteasome core complex, alpha-subunit complex; sarcomere

Molecular Function: endopeptidase activity; NF-kappaB binding; protein binding; purine ribonucleoside triphosphate binding; RNA binding

Biological Process: positive regulation of NF-kappaB transcription factor activity; proteasomal protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; proteolysis involved in protein catabolic process; regulation of inflammatory response

Disease: Myocardial Infarction, Susceptibility To

Reference #: P60900 (UniProtKB)

Alt. Names/Synonyms: 27 kDa prosomal protein; IOTA; Macropain iota chain; macropain subunit iota; MGC22756; MGC2333; MGC23846; Multicatalytic endopeptidase complex iota chain; p27K; PROS-27; PROS27; prosomal P27K protein; proteasome (prosome, macropain) subunit, alpha type, 6; proteasome 20S subunit alpha 6; Proteasome iota chain; proteasome subunit alpha 6; Proteasome subunit alpha type-6; proteasome subunit alpha1; proteasome subunit iota; PSA6; PSMA6; testicular secretory protein Li 44

Gene Symbols: PSMA6

Molecular weight: 27,399 Da

Basal Isoelectric point: 6.35 Predict pI for various phosphorylation states

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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PSMA6

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