PSAT1 Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. Expressed at high levels in the brain, liver, kidney and pancreas, and very weakly expressed in the thymus, prostate, testis and colon. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - glycine, serine and threonine; Cofactor and Vitamin Metabolism - vitamin B6; EC; Transferase
Chromosomal Location of mouse Ortholog: 19 A|19 10.86 cM
Cellular Component:  cytoplasm; cytosol
Molecular Function:  catalytic activity; identical protein binding; O-phospho-L-serine:2-oxoglutarate aminotransferase activity; pyridoxal phosphate binding; transaminase activity; transferase activity
Biological Process:  amino acid biosynthetic process; L-serine biosynthetic process
Reference #:  Q99K85 (UniProtKB)
Alt. Names/Synonyms: AL024078; AL024083; AU040266; D8Ertd814; D8Ertd814e; Endometrial progesterone-induced protein; EPIP; Phosphohydroxythreonine aminotransferase; Phosphoserine aminotransferase; phosphoserine aminotransferase 1; Psa; PSAT; Psat1; SERC
Gene Symbols: Psat1
Molecular weight: 40,473 Da
Basal Isoelectric point: 8.15  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene