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PSAT1
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. Expressed at high levels in the brain, liver, kidney and pancreas, and very weakly expressed in the thymus, prostate, testis and colon. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Amino Acid Metabolism - glycine, serine and threonine; Cofactor and Vitamin Metabolism - vitamin B6; EC 2.6.1.52; Transferase |
| Chromosomal Location of mouse Ortholog: 19 A|19 10.86 cM |
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Cellular Component:
cytoplasm; cytosol
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Molecular Function:
catalytic activity; identical protein binding; O-phospho-L-serine:2-oxoglutarate aminotransferase activity; pyridoxal phosphate binding; transaminase activity; transferase activity
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Biological Process:
amino acid biosynthetic process; L-serine biosynthetic process
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Reference #:
Q99K85
(UniProtKB)
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Alt. Names/Synonyms: AL024078; AL024083; AU040266; D8Ertd814; D8Ertd814e; Endometrial progesterone-induced protein; EPIP; Phosphohydroxythreonine aminotransferase; Phosphoserine aminotransferase; phosphoserine aminotransferase 1; Psa; PSAT; Psat1; SERC
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Gene Symbols: Psat1
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Molecular weight:
40,473 Da
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Basal Isoelectric point:
8.15
Predict pI for various phosphorylation states
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