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PSAT1
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. Expressed at high levels in the brain, liver, kidney and pancreas, and very weakly expressed in the thymus, prostate, testis and colon. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Amino Acid Metabolism - glycine, serine and threonine; Cofactor and Vitamin Metabolism - vitamin B6; EC 2.6.1.52; Transferase |
| Chromosomal Location of human Ortholog: 9q21.2 |
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Cellular Component:
cytoplasm; cytosol
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Molecular Function:
identical protein binding; O-phospho-L-serine:2-oxoglutarate aminotransferase activity; protein binding; pyridoxal phosphate binding
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Biological Process:
L-serine biosynthetic process; pyridoxine biosynthetic process
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Disease: Neu-laxova Syndrome 2; Phosphoserine Aminotransferase Deficiency
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Reference #:
Q9Y617
(UniProtKB)
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Alt. Names/Synonyms: endometrial progesterone-induced protein; EPIP; MGC1460; NLS2; Phosphohydroxythreonine aminotransferase; Phosphoserine aminotransferase; phosphoserine aminotransferase 1; PSA; PSAT; PSAT1; PSATD; SERC
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Gene Symbols: PSAT1
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Molecular weight:
40,423 Da
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Basal Isoelectric point:
7.56
Predict pI for various phosphorylation states
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