PSAT1 Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. Expressed at high levels in the brain, liver, kidney and pancreas, and very weakly expressed in the thymus, prostate, testis and colon. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - glycine, serine and threonine; Cofactor and Vitamin Metabolism - vitamin B6; EC; Transferase
Chromosomal Location of human Ortholog: 9q21.2
Cellular Component:  cytoplasm; cytosol
Molecular Function:  identical protein binding; O-phospho-L-serine:2-oxoglutarate aminotransferase activity; protein binding; pyridoxal phosphate binding
Biological Process:  L-serine biosynthetic process; pyridoxine biosynthetic process
Disease: Neu-laxova Syndrome 2; Phosphoserine Aminotransferase Deficiency
Reference #:  Q9Y617 (UniProtKB)
Alt. Names/Synonyms: endometrial progesterone-induced protein; EPIP; MGC1460; NLS2; Phosphohydroxythreonine aminotransferase; Phosphoserine aminotransferase; phosphoserine aminotransferase 1; PSA; PSAT; PSAT1; PSATD; SERC
Gene Symbols: PSAT1
Molecular weight: 40,423 Da
Basal Isoelectric point: 7.56  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein