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ULK2
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. Note: This description may include information from UniProtKB.
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| Protein type: Autophagy; EC 2.7.11.1; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); ULK family; ULK subfamily |
| Chromosomal Location of human Ortholog: 17p11.2 |
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Cellular Component:
autophagosome; cytoplasm; cytoplasmic vesicle membrane; cytosol; phagophore assembly site; phagophore assembly site membrane
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Molecular Function:
ATP binding; protein binding; protein serine kinase activity; protein serine/threonine kinase activity
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Biological Process:
autophagosome assembly; autophagy; autophagy of mitochondrion; axon extension; collateral sprouting; late nucleophagy; negative regulation of collateral sprouting; peptidyl-serine phosphorylation; piecemeal microautophagy of the nucleus; positive regulation of autophagy; protein autophosphorylation; response to starvation; reticulophagy; signal transduction
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Reference #:
Q8IYT8
(UniProtKB)
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Alt. Names/Synonyms: ATG1B; KIAA0623; Serine/threonine-protein kinase ULK2; ULK2; unc-51 like autophagy activating kinase 2; Unc-51-like kinase 2; unc-51-like kinase 2 (C. elegans); Unc51.2
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Gene Symbols: ULK2
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Molecular weight:
112,694 Da
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Basal Isoelectric point:
8.84
Predict pI for various phosphorylation states
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