PIGA Necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis. Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Membrane protein, integral; Transferase
Chromosomal Location of human Ortholog: Xp22.2
Cellular Component:  endoplasmic reticulum membrane; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex; integral component of membrane
Molecular Function:  phosphatidylinositol N-acetylglucosaminyltransferase activity; protein binding; UDP-glycosyltransferase activity
Biological Process:  cellular response to leukemia inhibitory factor; GPI anchor biosynthetic process; positive regulation of metabolic process; preassembly of GPI anchor in ER membrane
Disease: Multiple Congenital Anomalies-hypotonia-seizures Syndrome 2; Paroxysmal Nocturnal Hemoglobinuria 1
Reference #:  P37287 (UniProtKB)
Alt. Names/Synonyms: class A GlcNAc-inositol phospholipid assembly protein; GlcNAc-PI synthesis protein; GPI anchor biosynthesis; GPI3; MCAHS2; phosphatidylinositol glycan anchor biosynthesis class A; phosphatidylinositol glycan anchor biosynthesis, class A; Phosphatidylinositol N-acetylglucosaminyltransferase subunit A; Phosphatidylinositol-glycan biosynthesis class A protein; phosphatidylinositol-glycan biosynthesis, class A protein; PIG-A; PIGA; PNH1
Gene Symbols: PIGA
Molecular weight: 54,127 Da
Basal Isoelectric point: 8.63  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein