PAFAH1B1 Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position. Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos. Belongs to the WD repeat LIS1/nudF family. Fairly ubiquitous expression in both the frontal and occipital areas of the brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Lipid Metabolism - ether lipid
Chromosomal Location of Human Ortholog: 11 B5|11 45.76 cM
Cellular Component:  astral microtubule; axon; cell cortex; central region of growth cone; centrosome; cytoplasm; cytoplasmic microtubule; cytoskeleton; cytosol; growth cone; kinesin complex; kinetochore; membrane; microtubule; microtubule associated complex; microtubule cytoskeleton; motile cilium; neuron projection; neuronal cell body; nuclear envelope; nucleus; perinuclear region of cytoplasm; stereocilium; vesicle
Molecular Function:  dynein complex binding; dynein intermediate chain binding; microtubule binding; microtubule plus-end binding; phosphoprotein binding; protein binding; protein homodimerization activity; protein-containing complex binding
Biological Process:  acrosome assembly; actin cytoskeleton organization; adult locomotory behavior; ameboidal-type cell migration; auditory receptor cell development; brain morphogenesis; cell cycle; cell differentiation; cell division; cell migration; cerebral cortex development; cerebral cortex neuron differentiation; chemical synaptic transmission; cochlea development; corpus callosum morphogenesis; cortical microtubule organization; establishment of centrosome localization; establishment of mitotic spindle orientation; establishment of planar polarity of embryonic epithelium; hippocampus development; layer formation in cerebral cortex; learning or memory; lipid catabolic process; lipid metabolic process; maintenance of centrosome location; microtubule cytoskeleton organization; microtubule cytoskeleton organization involved in establishment of planar polarity; microtubule organizing center organization; microtubule-based process; multicellular organism development; negative regulation of JNK cascade; negative regulation of neuron projection development; nervous system development; neuroblast proliferation; neuromuscular process controlling balance; neuron migration; nuclear envelope disassembly; nuclear migration; osteoclast development; positive regulation of axon extension; positive regulation of cellular component organization; positive regulation of cytokine-mediated signaling pathway; positive regulation of dendritic spine morphogenesis; positive regulation of embryonic development; positive regulation of mitotic cell cycle; protein secretion; regulation of GTPase activity; regulation of microtubule cytoskeleton organization; regulation of microtubule motor activity; retrograde axonal transport; stem cell division; transmission of nerve impulse; vesicle transport along microtubule
Reference #:  P63005 (UniProtKB)
Alt. Names/Synonyms: LIS-1; Lis1; Lissencephaly-1 protein; Mds; Mdsh; MGC25297; MMS10-U; Ms10u; OTTMUSP00000006469; OTTMUSP00000006470; PAF acetylhydrolase 45 kDa subunit; PAF-AH 45 kDa subunit; PAF-AH alpha; PAFAH alpha; Pafah1b1; Pafaha; Pafaha/Lis1; platelet-activating factor acetylhydrolase 1b, regulatory subunit 1; platelet-activating factor acetylhydrolase 45kD subunit; platelet-activating factor acetylhydrolase IB alpha subunit; Platelet-activating factor acetylhydrolase IB subunit alpha; platelet-activating factor acetylhydrolase, isoform 1b, beta1 subunit; platelet-activating factor acetylhydrolase, isoform 1b, subunit 1; RP23-194P5.2; truncated form platelet-activating factor acetylhydrolase 45kD subunit
Gene Symbols: Pafah1b1
Molecular weight: 46,670 Da
Basal Isoelectric point: 6.97  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PAFAH1B1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene