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P2Y6
Receptor for extracellular UDP Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of human Ortholog: 11q13.4 |
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Cellular Component:
apical plasma membrane; basolateral plasma membrane; plasma membrane
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Molecular Function:
G protein-coupled ADP receptor activity; G protein-coupled receptor activity; G protein-coupled UDP receptor activity; G protein-coupled UTP receptor activity; protein binding
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Biological Process:
activation of phospholipase C activity; cellular response to prostaglandin E stimulus; cellular response to purine-containing compound; cellular response to pyrimidine ribonucleotide; G protein-coupled purinergic nucleotide receptor signaling pathway; G protein-coupled receptor signaling pathway; phagocytosis; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of ERK1 and ERK2 cascade; positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; positive regulation of inositol trisphosphate biosynthetic process; positive regulation of smooth muscle cell migration; positive regulation of vascular associated smooth muscle cell proliferation; transepithelial chloride transport
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Reference #:
Q15077
(UniProtKB)
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Alt. Names/Synonyms: G-coupled nucleotide receptor; MGC15335; P2 purinoceptor; P2RY6; P2Y purinoceptor 6; P2Y6; P2Y6 receptor; pyrimidinergic receptor P2Y, G-protein coupled, 6; pyrimidinergic receptor P2Y6
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Gene Symbols: P2RY6
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Molecular weight:
36,429 Da
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Basal Isoelectric point:
9.61
Predict pI for various phosphorylation states
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