CDC7 Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily. 1 alternatively spliced human isoform has been reported. Note: This description may include information from UniProtKB.
Protein type: CDC7 family; EC; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: 1p22.2-p22.1
Cellular Component:  cytoplasm; intercellular bridge; mitotic spindle; nucleoplasm; nucleus
Molecular Function:  ATP binding; kinase activity; metal ion binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity
Biological Process:  cell cycle phase transition; cell division; double-strand break repair via break-induced replication; G1/S transition of mitotic cell cycle; peptidyl-serine phosphorylation; positive regulation of cell population proliferation; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of nuclear cell cycle DNA replication; signal transduction
Reference #:  O00311 (UniProtKB)
Alt. Names/Synonyms: CDC7; CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like 1; CDC7-related kinase; CDC7L1; cell division cycle 7; cell division cycle 7 homolog; cell division cycle 7 homolog (S. cerevisiae); cell division cycle 7-like protein 1; Cell division cycle 7-related protein kinase; DDK; epididymis secretory sperm binding protein; HsCdc7; Hsk1; huCdc7; MGC117361; MGC126237; MGC126238
Gene Symbols: CDC7
Molecular weight: 63,888 Da
Basal Isoelectric point: 8.96  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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