MRC1 Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. (Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens. (Microbial infection) Acts as a receptor for Dengue virus envelope protein E. (Microbial infection) Interacts with Hepatitis B virus envelope protein. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of mouse Ortholog: 2 A2|2 10.46 cM
Cellular Component:  cell surface; endosome; endosome membrane; integral component of membrane; membrane; plasma membrane
Molecular Function:  carbohydrate binding; cargo receptor activity; mannose binding; transmembrane signaling receptor activity
Biological Process:  cellular response to interferon-gamma; cellular response to interleukin-4; cellular response to lipopolysaccharide; endocytosis; receptor-mediated endocytosis
Reference #:  Q61830 (UniProtKB)
Alt. Names/Synonyms: AW259686; CD206; Macrophage mannose receptor 1; mannose receptor, C type 1; MMR; MR; Mrc1; OTTMUSP00000012205
Gene Symbols: Mrc1
Molecular weight: 164,981 Da
Basal Isoelectric point: 6.41  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene