MRC1 Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. (Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens. (Microbial infection) Acts as a receptor for Dengue virus envelope protein E. (Microbial infection) Interacts with Hepatitis B virus envelope protein. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of human Ortholog: 10p12.33
Cellular Component:  cell surface; endosome membrane; integral component of plasma membrane; plasma membrane
Molecular Function:  cargo receptor activity; mannose binding; protein binding; virus receptor activity
Biological Process:  cellular response to interferon-gamma; cellular response to interleukin-4; cellular response to lipopolysaccharide; receptor-mediated endocytosis; viral entry into host cell
Reference #:  P22897 (UniProtKB)
Alt. Names/Synonyms: bA541I19.1; C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; CD206; CLEC13D; CLEC13DL; hMR; Human mannose receptor; Macrophage mannose receptor 1; Macrophage mannose receptor 1-like protein 1; Mannose receptor; mannose receptor C type 1; mannose receptor C-type 1; mannose receptor, C type 1; mannose receptor, C type 1-like 1; MMR; MRC1; MRC1L1
Gene Symbols: MRC1
Molecular weight: 166,012 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein