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MORF4L1
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Transcription, coactivator/corepressor |
| Chromosomal Location of human Ortholog: 15q25.1 |
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Cellular Component:
NuA4 histone acetyltransferase complex; nuclear speck; nucleoplasm; nucleosome; Sin3 complex
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Molecular Function:
chromatin binding; protein binding
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Biological Process:
chromatin organization; double-strand break repair via homologous recombination; fibroblast proliferation; histone acetylation; histone H2A acetylation; histone H4 acetylation; positive regulation of DNA-templated transcription; positive regulation of double-strand break repair via homologous recombination; regulation of apoptotic process; regulation of cell cycle; regulation of double-strand break repair
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Reference #:
Q9UBU8
(UniProtKB)
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Alt. Names/Synonyms: Eaf3; Esa1p-associated factor 3 homolog; FWP006; HsT17725; MEAF3; MGC10631; MO4L1; MORF-related gene 15 protein; MORF-related gene on chromosome 15; MORF4L1; MORFRG15; mortality factor 4 like 1; Mortality factor 4-like protein 1; MRG15; Protein MSL3-1; S863-6; Transcription factor-like protein MRG15
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Gene Symbols: MORF4L1
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Molecular weight:
41,474 Da
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Basal Isoelectric point:
9.29
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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