galectin-9 Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. It is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death. Isoform Short acts as an eosinophil chemoattractant. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 11|11 B5
Cellular Component:  cytoplasm; cytosol; extracellular region; nucleus
Molecular Function:  carbohydrate binding; enzyme binding; galactoside binding; protein binding; protein serine/threonine kinase activator activity; signaling receptor binding
Biological Process:  cellular response to virus; chemotaxis; female pregnancy; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; immune system process; maintenance of protein location; negative regulation of CD4-positive, alpha-beta T cell proliferation; negative regulation of gene expression; negative regulation of inflammatory response; negative regulation of interferon-gamma production; negative regulation of interferon-gamma secretion; negative regulation of natural killer cell activation; negative regulation of natural killer cell degranulation; positive regulation of chemokine production; positive regulation of cytokine production; positive regulation of defense response to bacterium; positive regulation of gene expression; positive regulation of innate immune response; positive regulation of interleukin-1 production; positive regulation of interleukin-10 secretion; positive regulation of interleukin-6 secretion; positive regulation of macrophage activation; positive regulation of oxidoreductase activity; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of regulatory T cell differentiation; positive regulation of T cell migration; positive regulation of transcription regulatory region DNA binding; positive regulation of tumor necrosis factor production; regulation of natural killer cell differentiation; response to lipopolysaccharide; toll-like receptor 3 signaling pathway
Reference #:  O08573 (UniProtKB)
Alt. Names/Synonyms: AA407335; AI194909; AI265545; Gal-9; Galectin-9; lectin, galactose binding, soluble 5; lectin, galactose binding, soluble 9; LEG9; LGALS35; Lgals5; Lgals9
Gene Symbols: Lgals9
Molecular weight: 40,036 Da
Basal Isoelectric point: 9.41  Predict pI for various phosphorylation states
Select Structure to View Below

galectin-9

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene