GJB3 One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Belongs to the connexin family. Beta-type (group I) subfamily. Note: This description may include information from UniProtKB.
Protein type: Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of human Ortholog: 1p34.3
Cellular Component:  cell junction; connexin complex; cytoplasm; gap junction; intracellular membrane-bounded organelle
Molecular Function:  gap junction channel activity; protein binding
Biological Process:  cell-cell signaling; cellular response to retinoic acid; in utero embryonic development; placenta development; skin development; spermatogenesis; transmembrane transport
Disease: Deafness, Autosomal Dominant 2b; Deafness, Autosomal Recessive 1a; Erythrokeratodermia Variabilis Et Progressiva
Reference #:  O75712 (UniProtKB)
Alt. Names/Synonyms: connexin 31; Connexin-31; CX31; CXB3; DFNA2; DFNA2B; EKV; EKVP1; FLJ22486; Gap junction beta-3 protein; gap junction protein beta 3; gap junction protein, beta 3, 31kDa; GJB3; MGC102938
Gene Symbols: GJB3
Molecular weight: 30,818 Da
Basal Isoelectric point: 8.94  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein