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PAR3
Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. Belongs to the G-protein coupled receptor 1 family. Highest expression in the megakaryocytes of the bone marrow, lower in mature megakaryocytes, in platelets and in a variety of other tissues such as heart and gut. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of mouse Ortholog: 13 D1|13 50.38 cM |
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Cellular Component:
apical plasma membrane; membrane; plasma membrane; protein-containing complex
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Molecular Function:
G protein-coupled receptor activity; proteinase-activated receptor activity; receptor ligand activity; thrombin-activated receptor activity
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Biological Process:
blood coagulation; G protein-coupled receptor signaling pathway; hemostasis; ligand-gated ion channel signaling pathway; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; positive regulation of insulin secretion; positive regulation of Rho protein signal transduction; signal transduction; thrombin-activated receptor signaling pathway
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Reference #:
O08675
(UniProtKB)
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Alt. Names/Synonyms: coagulation factor II (thrombin) receptor-like 2; Coagulation factor II receptor-like 2; F2rl2; F730031A08; PAR-3; Par3; protease-activated receptor 3; Proteinase activated receptor 3 precursor (PAR-3) (Thrombin receptor-like 2) (Coagulation factor II receptor-like 2); Proteinase-activated receptor 3; Thrombin receptor-like 2
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Gene Symbols: F2rl2
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Molecular weight:
41,697 Da
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Basal Isoelectric point:
8.16
Predict pI for various phosphorylation states
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