PAR3 a G-protein coupled receptor for activated thrombin or trypsin. Coupled to G proteins that stimulate phosphoinositide hydrolysis. Interacts with INSC/inscuteable and probably GPSM2. Highest expression in the megakaryocytes of the bone marrow, lower in mature megakaryocytes, in platelets and in a variety of other tissues such as heart and gut. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 5q13.3
Cellular Component:  apical plasma membrane; extracellular region; plasma membrane; protein-containing complex
Molecular Function:  phosphatidylinositol phospholipase C activity; protein binding; thrombin-activated receptor activity
Biological Process:  blood coagulation; G protein-coupled receptor signaling pathway; platelet activation; response to wounding; thrombin-activated receptor signaling pathway
Reference #:  O00254 (UniProtKB)
Alt. Names/Synonyms: coagulation factor II (thrombin) receptor-like 2; Coagulation factor II receptor-like 2; Coagulation factor II receptor-like 2 (protease-actovated receptor 3); F2RL2; PAR-3; PAR3; protease-activated receptor 3; Proteinase-activated receptor 3; proteinase-activated receptor-3; Thrombin receptor-like 2
Gene Symbols: F2RL2
Molecular weight: 42,508 Da
Basal Isoelectric point: 8.56  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene