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EXTL3
Glycosyltransferase which regulates the biosynthesis of heparan sulfate (HS). Important for both skeletal development and hematopoiesis, through the formation of HS proteoglycans (HSPGs). Required for the function of REG3A in regulating keratinocyte proliferation and differentiation. Belongs to the glycosyltransferase 47 family. Ubiquitous. Expressed in keratinocytes. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.4.1.223; Glycan Metabolism - heparan sulfate biosynthesis; Membrane protein, integral; Transferase |
| Chromosomal Location of Human Ortholog: 14|14 D1 |
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Cellular Component:
endoplasmic reticulum; Golgi apparatus; integral component of membrane; membrane
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Molecular Function:
glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; metal ion binding; transferase activity; transferase activity, transferring glycosyl groups
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Biological Process:
heparan sulfate proteoglycan biosynthetic process; positive regulation of cell growth; protein glycosylation
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Reference #:
Q9WVL6
(UniProtKB)
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Alt. Names/Synonyms: 2900009G18Rik; AU040105; exostoses (multiple)-like 3; exostoses-like 3; exostosin; Exostosin-like 3; Ext1l; Extl3; Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; KIAA0519; mKIAA0519; Multiple exostosis-like protein 3
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Gene Symbols: Extl3
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Molecular weight:
104,474 Da
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Basal Isoelectric point:
6.15
Predict pI for various phosphorylation states
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