EXTL3 Glycosyltransferase which regulates the biosynthesis of heparan sulfate (HS). Important for both skeletal development and hematopoiesis, through the formation of HS proteoglycans (HSPGs). Required for the function of REG3A in regulating keratinocyte proliferation and differentiation. Belongs to the glycosyltransferase 47 family. Ubiquitous. Expressed in keratinocytes. Note: This description may include information from UniProtKB.
Protein type: EC; Glycan Metabolism - heparan sulfate biosynthesis; Membrane protein, integral; Transferase
Chromosomal Location of Human Ortholog: 14|14 D1
Cellular Component:  endoplasmic reticulum; Golgi apparatus; integral component of membrane; membrane
Molecular Function:  glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; metal ion binding; transferase activity; transferase activity, transferring glycosyl groups
Biological Process:  heparan sulfate proteoglycan biosynthetic process; positive regulation of cell growth; protein glycosylation
Reference #:  Q9WVL6 (UniProtKB)
Alt. Names/Synonyms: 2900009G18Rik; AU040105; exostoses (multiple)-like 3; exostoses-like 3; exostosin; Exostosin-like 3; exostosin-like glycosyltransferase 3; Ext1l; Extl3; Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; KIAA0519; mKIAA0519; Multiple exostosis-like protein 3
Gene Symbols: Extl3
Molecular weight: 104,474 Da
Basal Isoelectric point: 6.15  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene