DOK5 DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation. Belongs to the DOK family. Type B subfamily. Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 2 H3|2 92.26 cM
Cellular Component: 
Molecular Function:  protein binding
Biological Process:  neuron differentiation; positive regulation of MAPK cascade; regulation of neurotrophin TRK receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  Q91ZM9 (UniProtKB)
Alt. Names/Synonyms: 2700055C10Rik; Docking protein 5; Dok5; Downstream of tyrosine kinase 5; OTTMUSP00000017257
Gene Symbols: Dok5
Molecular weight: 35,453 Da
Basal Isoelectric point: 9.01  Predict pI for various phosphorylation states
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DOK5

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene