CYP1A2 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O- deethylation of phenacetin. Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - tryptophan; Cofactor and Vitamin Metabolism - retinol; EC; Lipid Metabolism - linoleic acid; Oxidoreductase; Secondary Metabolites Metabolism - caffeine; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450
Chromosomal Location of Human Ortholog: 9 B|9 31.3 cM
Cellular Component:  endoplasmic reticulum; intracellular membrane-bounded organelle; membrane
Molecular Function:  aromatase activity; caffeine oxidase activity; demethylase activity; enzyme binding; heme binding; iron ion binding; metal ion binding; monooxygenase activity; oxidoreductase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Biological Process:  alkaloid metabolic process; cellular aromatic compound metabolic process; cellular respiration; cellular response to cadmium ion; dibenzo-p-dioxin metabolic process; drug catabolic process; drug metabolic process; exogenous drug catabolic process; heterocycle metabolic process; hydrogen peroxide biosynthetic process; lipid metabolic process; lung development; monocarboxylic acid metabolic process; monoterpenoid metabolic process; oxidation-reduction process; oxidative deethylation; oxidative demethylation; porphyrin-containing compound metabolic process; post-embryonic development; regulation of gene expression; steroid catabolic process; steroid metabolic process; toxin biosynthetic process; toxin metabolic process
Reference #:  P00186 (UniProtKB)
Alt. Names/Synonyms: aromatic compound inducible; CP12; CP1A2; Cyp1a-2; Cyp1a1; Cyp1a2; CYPIA2; Cytochrome P450 1A2; cytochrome P450 family 1 subfamily a polypeptide 1; cytochrome P450, 1a2, aromatic compound inducible; cytochrome P450, family 1, subfamily a, polypeptide 2; Cytochrome P450-P2; Cytochrome P450-P3; P450-3
Gene Symbols: Cyp1a2
Molecular weight: 58,184 Da
Basal Isoelectric point: 8.92  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene